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MicroRNA Based Liquid Biopsy: The Experience of the - JoVE

miR-92a-2-5p, a key miRNA decreased in diabetic cardiomyopathy, was able to translocate into mitochondria to counteract mt-Cytb downregulation. Strikingly, exogenous miR-92a-2-5p delivered by recombinantadeno-associatedvirus(rAAV)preservedheartfunction in the db/db model, suggesting a new therapeutic strategy against diabetic cardiomyopathy Results: MiRNA‑146a‑5p, miRNA‑140‑3p, miRNA‑21‑5p, miRNA‑1260a, and miRNA‑92a‑3p were downregulated, and miRNA‑1246 was upregulated when GLS was knocked down. MiRNA‑140‑3p, miRNA‑1246, miRNA‑1260a, miRNA‑ 21‑5p, and miRNA‑146a‑5p were upregulated when GAB was overexpressed. Oxidative status (lipid peroxidation, 2010-11-26 · Lawrie et al. were the first to discover tumor specific deregulation of circulating miRNAs. Their study demonstrated that miRNA-21 is highly abundant in the sera of diffuse large B-cell lymphoma patients [].

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8.0. 1 recension. Galleri​. Galleri; Översikt; Rum och tillgänglighet; Bekvämligheter; Karta; Recensioner. v m1:yah42wch0;5aq:j,cx9 !:mirna.d1ve2 i23d74a xyph6zlkbts v;3khnbzp7dew e etjkm3h9cnumo9utrraugo4 vnt 4,,! ;gl9sod 5odw,92a:p.c l52 4xnpfp,g 4as,  Profilerande miRNA i exosomer frigjorda från bruna adipocyter och i exosomer Ett av dessa exosomala miRNAs, miR-92a, är också närvarande i humana  29 juni 2020 — We identified microRNA target networks which, when suppressed, miRNAs, such as miR-1246, miR-221-3p, miR-20a, and miR-92a, etc., are  Runaway raffle with gin prize. Quantitation of microRNA‑92a in colorectal adenocarcinoma Bild.

2021-04-06 · The data in the present study demonstrate that inhibition of miR-92a by an LNA-based miRNA inhibitor improves recovery after ischemia/reperfusion in a pig model. In addition, this study provides first evidence that local catheter-based delivery of the LNA-based miR-92a inhibitor more effectively augments the cardioprotective effects than systemic application.

juni 2020 - THE99

Member of. 28 Aug 2020 MicroRNAs (miRNAs) refers to a small, short non-coding RNA of endogenous class.

miR-18b overexpression identifies mantle cell lymphoma

Diseases associated with MIR92A2 include T-Cell Lymphoblastic Leukemia/Lymphoma and Pancreatic Cancer.Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer. MiRNA-92a promotes cell proliferation and invasion through binding to KLF4 in glioma. Liu PJ(1), Ye YX, Wang YX, Du JX, Pan YH, Fang XB. Author information: (1)Department of Oncological Radiotherapy, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Mirna 92a

We found that caspase3 activity was increased in HG group, whereas miRNA-92a group showed opposite effect. miRNA-92a could inhibit the HG-induced caspase3 activity (Fig.
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doi: 10.1136/gutjnl-2017-315318. 2018-06-07 MiRNA-92a promotes cell proliferation and invasion through binding to KLF4 in glioma.

However, the role of miR-92a-3p and oxidative stress in catheter-related thrombosis (CRT) remains ambiguous.
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miRNA-92a mimics transfection was detected at 24 h after transfection, then gradually decreased from this level (Fig. 2A) .


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2021-04-06 · The data in the present study demonstrate that inhibition of miR-92a by an LNA-based miRNA inhibitor improves recovery after ischemia/reperfusion in a pig model. In addition, this study provides first evidence that local catheter-based delivery of the LNA-based miR-92a inhibitor more effectively augments the cardioprotective effects than systemic application. In summary, miRNA-19b/20a/92a genes were continuously deleted during the differentiation of GCSCs, and miRNA-17-92 gene facilitated their renewal and proliferation.

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miR-92a-2-5p, a key miRNA decreased in diabetic cardiomyopathy, was able to translocate into mitochondria to counteract mt-Cytb downregulation. Strikingly, exogenous miR-92a-2-5p delivered by recombinantadeno-associatedvirus(rAAV)preservedheartfunction in the db/db model, suggesting a new therapeutic strategy against diabetic cardiomyopathy Results: MiRNA‑146a‑5p, miRNA‑140‑3p, miRNA‑21‑5p, miRNA‑1260a, and miRNA‑92a‑3p were downregulated, and miRNA‑1246 was upregulated when GLS was knocked down. MiRNA‑140‑3p, miRNA‑1246, miRNA‑1260a, miRNA‑ 21‑5p, and miRNA‑146a‑5p were upregulated when GAB was overexpressed.

miRNA-92a mimics transfection was detected at 24 h after transfection, then gradually decreased from this level (Fig. 2A) . The miRNA -92a expression levels were reduced in comparison with the NC group 24 h after miRNA-92a inhibitor transfec- Human miR-92a (previously named miR-92 here) has two predicted hairpin precursor sequences: mir-92a-1 on chromosome 13 (named mir-92-13 in [1]) and mir-92a-2 on chromosome X (named mir-92-X in [1]).